I have built a couple sets of these very large doors, and worried often about the glue. You can call Franklin(and I have), and they will claim that on well-fitting, long grain joints, and also mortise and tenon joints, their exterior titebond has greater strength than epoxy.
You just might want to consider this. I admit that because my doors were very large/complex to glue up, I used epoxy anyway.
If I were designing doors and wanted to leave the panel out until after the rails/stiles were glued up, I would make the exterior mold on the rail/stile(if possible), and apply the interior mold after glue-up, so the nails would be to the interior.
Epoxy will make a good filler for small spots on the exterior, especially on dark-colored doors(this is all I have made- not sure how that would work if using light-colored wood)